Handyscope HS4 DIFF USB oscilloscope

A differential USB oscilloscope

Base price:  982.00

A differential 4 channel, 50 MHz USB oscilloscope from TiePie engineering.

Key specifications

  • Differential inputs
  • 12, 14, 16 bit resolution, 0.3 % DC accuracy
  • Up to 50 MSa/s sampling, 50 MHz bandwidth
  • 128 KSamples memory per channel

Full specifications Data sheet Manual Request info

Base model:
  • Handyscope HS4 DIFF-50
  • Handyscope HS4 DIFF-25
  • Handyscope HS4 DIFF-10
  • Handyscope HS4 DIFF-5

Order code:

The Handyscope HS4 DIFF is a 4 channel differential USB oscilloscope with a maximum sampling speed of 50MSa/s and 128 Kpts memory per channel. The differential input channels enable safely measuring, without risk of creating a short circuit through the oscilloscope. The Handyscope HS4 DIFF is delivered with a complete measurement software package that offers all you need for your measurement applications.

Differential inputs

The Handyscope HS4 DIFF features four isolated differential input channels. This makes it the ideal instrument to perform measurements in high voltage circuits, amplifiers, switch mode power supplies, power inverters etc. No more risk of creating short circuits through your oscilloscope!

Read more about differential measuring

Diff input

Fast continuous streaming

Besides measuring in block mode as oscilloscope, the Handyscope HS4 DIFF is also capable of performing continuous streaming measurements as data logger. This will create a continuous uninterrupted data stream to the computer. The data can then be displayed on the screen and/or saved to disk.

Read more about streaming measurements

WiFiScope Front sideview

Combining multiple Handyscope HS4 DIFFs

When one Handyscope HS4 DIFF does not offer enough input channels, the Handyscope HS4 DIFF can be coupled to one or more other instruments. This allows to make a combined instrument which will enable simultaneous measuring on all channels of all combined instruments.

Read more about combining instruments

Synchronize oscilloscopes

Versatile Multi Channel oscilloscope software

The Handyscope HS4 DIFF is delivered with the versatile Multi Channel oscilloscope software, which transforms the Handyscope HS4 DIFF into an oscilloscope, spectrum analyzer, data logger, multimeter and protocol analyzer.

Some of the powerful features of the Multi Channel oscilloscope software are indicated below, for a full description of the Multi Channel oscilloscope software, refer to the Multi Channel oscilloscope software pages.

Flexible signal displays

The Multi Channel oscilloscope software scope, spectrum analyzer and datalogger offer an ultimately flexible way to display all aspects of the measured signals. They can have one or more graphs, each displaying one or more signals, where each graph can display different parts of a signal. Graphs can display the signal(s) of your Handyscope in Yt mode, in XY mode or as frequency spectrum, with or without interpolation. Colors of all items in a graph can be set to any required value. Graph dimensions can be adjusted to any required size, graphs can be located in one single window or in separate windows, which can be located anywhere on the desktop.

Read more on Graphs...

Touchscreen friendly toolbars

An oscilloscope toolbar and channel toolbars are available for each detected Handyscope. The convenient toolbars provide clear buttons for all settings of the oscilloscope and its channels. They show the current settings of the oscilloscope and allow to change all settings. The large buttons are very suitable for touchscreen operation.

The toolbars are fully configurable through the program settings. You can set the button size, add or remove buttons and change the order of the buttons.

Read more on oscilloscope toolbars... Read more on channel toolbars...

Many automatic measurements

The Multi Channel oscilloscope software features many automatic measurements, that can be performed on the measured signals of your Handyscope or on a selection of the measured signals. Using the automatic measurements in the oscilloscope, any detail of your signal is revealed. Two sets of cursors, both horizontal and vertical, can be used to indicate a part of the signal that needs to be examined thoroughly. The automatic measurements include e.g.: Mininum, Maximum, Top-Bottom, RMS, Mean, Variance, Standard deviation, Frequency.

The measurement results are shown in a special value window that can be positioned anywhere on your computer screen. A convenient toolbar allows you to enable or disable a measurement with a single click. The measurement results can be copied to the clipboard e.g. to use them in reports. When printing the graphs, the cursors and measurements results are also included.

Read more on cursors and measurements...


The multimeter in the Multi Channel oscilloscope software turns your Handyscope into a multimeter can be used to measure or monitor specific properties of a signal, like True RMS value, frequency, maximum value etc. The Multi Channel oscilloscope software multimeter can have any number of fully configurable displays, either displaying the measured value as a number or using a gauge display. When using a gauge display, it can be very helpful when adjusting a circuit for a specific property, e.g. adjusting an offset to zero.

Read more on the Multimeter...

More features

To discover more features of the comprehensive Multi Channel oscilloscope software for your Handyscope HS4 DIFF, visit the Multi Channel oscilloscope software pages for a full description.

Handyscope HS4 DIFF specifications

The tables below show detailed specifications of the Handyscope HS4 DIFF. Jump to acquisition specifications, trigger specifications or general specifications.

Acquisition system

Number of input channels4 analog
Ch1, Ch2, Ch3, Ch4Isolated BNC, female
ResolutionUser selectable in software
Native12 bit
Enhanced14, 16 bit
Accuracy0.3 % of full scale ± 1 LSB
Noise135 µVrms (200 mV range, 12 bit, 50 MSa/s)
50 µVrms (200 mV range, 16 bit, 195 kSa/s)
Ranges (Full scale)±200 mV
±400 mV
±800 mV
±2 V
±4 V
±8 V
±20 V
±40 V
±80 V
Impedance2 MΩ / 40 pF
Maximum input voltage (in all ranges)±200 V (DC + AC peak < 10 kHz)
with 1:10 attenuator ±300 V (DC + AC peak < 10 kHz)
Maximum Common Mode voltage200 mV to 800 mV ranges : 2 V
2 V to 8 V ranges : 20 V
20 V to 80 V ranges : 200 V
Common Mode Rejection Ratio-48 dB
Bandwidth (-3dB)DC to 50 MHz maximum
AC coupling cut off frequency (-3dB)1 Hz
Channel Isolation500 V
Channel Separation-80 dB
Maximum sampling rateHS4 DIFF-50HS4 DIFF-25HS4 DIFF-10HS4 DIFF-5
12 bit50 MSa/s25 MSa/s10 MSa/s5 MSa/s
14 bit3.125 MSa/s3.125 MSa/s3.125 MSa/s3.125 MSa/s
16 bit195.3 kSa/s195.3 kSa/s195.3 kSa/s195.3 kSa/s
Maximum streaming rateHS4 DIFF-50HS4 DIFF-25HS4 DIFF-10HS4 DIFF-5
12 bit500 kSa/s250 kSa/s100 kSa/s50 kSa/s
14 bit480.8 kSa/s250 kSa/s99.2 kSa/s50 kSa/s
16 bit195.3 kSa/s195.3 kSa/s97.7 kSa/s48.8 kSa/s
Sampling clock source 
Accuracy±0.01 %
Stability±100 ppm over -40 °C to +85 °C
Time base aging±5 ppm/year
ExternalOn extension connector
Voltage3.3 V TTL, 5 V TTL tolerant
Frequency range95 MHz to 105 MHz
Memory128 Kpts per channel
SystemDigital, 2 levels
SourceCH1, CH2, CH3, CH4, OR, digital external
Trigger modesRising edge, Falling edge
Inside window, Outside window
Level adjustment0 to 100 % of full scale
Hysteresis adjustment0 to 100 % of full scale
Resolution0.025 % (12 bits)
Pre trigger0 to 131071 samples, 1 sample resolution
Post trigger0 to 131071 samples, 1 sample resolution
Trigger hold-off0 to 1048576 Samples, 1 sample resolution
Digital external trigger 
InputExtension connector
Range0 to 3.3 V (5 V max)


InterfaceUSB 2.0 High Speed (480 Mbit/s); (USB 1.1 Full Speed (12 Mbit/s) and USB 3.0 compatible)

Power Requirements

Power from USB port500 mA max (2.5 W max)
Power via external power input / extension connector1500 mA max (7.5 W max)
Minimum voltage4.5 VDC
Maximum voltage14 VDC


Instrument height25 mm (1 inch)
Instrument length170 mm (6.7 inch)
Instrument width140 mm (5.2 inch)
Cord length1.8 m (70 inch)
Weight460 g (16 ounce)

I/O connectors

Channel 1...4Isolated BNC, female
USBfixed cable with USB 2.0 and USB 1.1 type A connector
Extension connectorD-sub 25 pins female

System Requirements

PC I/O connectionUSB 2.0 High Speed (480 Mbit/s); (USB 1.1 Full Speed (12 Mbit/s) and USB 3.0 compatible)
Operating SystemWindows 10 / 11 and Linux (via libtiepie-hw SDK)

Operating Environment

Ambient temperature0 to 55 °C
Relative humidity10 to 90% non condensing

Storage Environment

Ambient temperature-20 to 70 °C
Relative humidity5 to 95% non condensing

Certifications and Compliances

CE mark complianceYes


Convenient carrying case 
InstrumentHandyscope HS4 DIFF
Measure leads4 x Measure lead TP-C812B, BNC -> 4 mm banana plug
Accessories4 x Differential attenuator TP-DA10
external power cable for second USB port
SoftwareWindows 10 / 11, via website
DriversWindows 10 / 11, via website
Software Development Kitfor Windows 10 / 11 and Linux, via website
Manualinstrument manual and software user's manuals
color printed on paper and digital, via website
Total package weightApprox. 3 kg

The Handyscope HS4 DIFF is available in 4 different models that distinguish in maximum sampling rate and maximum streaming rate:

Order codeMax. sampling speedMax. streaming speed
HS4-DIFF-5050 MSa/s500 KSa/s
HS4-DIFF-2525 MSa/s250 KSa/s
HS4-DIFF-1010 MSa/s100 KSa/s
HS4-DIFF-55 MSa/s50 KSa/s

Available options for the Handyscope HS4 DIFF are:

  • W5: With the extended warranty option, warranty is five years on parts and labor. Without this option, the models have two years warranty on parts and labor.

View complete list of all models

The Handyscope HS4 DIFF is delivered with:

Cary case Carry case BT341
Instrument Handyscope HS4 DIFF
Measure leads 4 x Measure lead TP-C812B, Differential BNC -> 4 mm banana plug
Differential attenuator 4 x Differential attenuator TP-DA10
Accessories external power cable for USB port
Software for Windows 10 / 11, via website
Drivers for Windows 10 / 11, via website
Software Development Kit for Windows 10 / 11 and Linux, via website
Manuals instrument manual and software user's manuals
color printed and digital via website
Complete set

Several downloads for the Handyscope HS4 DIFF are listed below, including Multi Channel oscilloscope software, drivers and manuals.

Driver & Software

WinUSB driver10.0.2Windows 10 / 11, 64 bit1.73 MB download
Multi Channel software1.47.0Windows 10 / 11, 64 bit, including PDF manual103.76 MB download

Manuals & Documents

Multi Channel software manual 1.11English3.13 MB download
Handyscope HS4 DIFF Instrument manual2.48English715.92 kB download
Handyscope HS4 DIFF DatasheetEnglish4.09 MB download

Software Development Kit (SDK)

Interfacing the Handyscope HS4 DIFF with third party software and developing own software requires the libtiepie-hw Software Development Kit. Detailed information on the libtiepie-hw SDK, downloads for Windows and Linux platforms and bindings and programming examples for various programming environments can be found in the libtiepie-hw pages.